Protein name:
Ubiquitin thioesterase otulin ;
Alternative:
OTU domain-containing deubiquitinase with linear linkage specificity ;Deubiquitinating enzyme otulin ;Ubiquitin thioesterase Gumby ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with RNF31; the interaction is direct.
Function:
Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MSRGTMPQPE | AWPGASCAET | PAREAAATAR | DGGKAAASGQ | PRPEMQCPAE |
100:
HEEDMYRAAD | EIEKEKELLI | HERGASEPRL | SVAPEMDIMD | YCKKEWRGNT |
150:
QKATCMKMGY | EEVSQKFTSI | RRVRGDNYCA | LRATLFQAMS | QAVGLPPWLQ |
200:
DPELMLLPEK | LISKYNWIKQ | WKLGLKFDGK | NEDLVDKIKE | SLTLLRKKWA |
250:
GLAEMRTAEA | RQIACDELFT | NEAEEYSLYE | AVKFLMLNRA | IELYNDKEKG |
300:
KEVPFFSVLL | FARDTSNDPG | QLLRNHLNQV | GHTGGLEQVE | MFLLAYAVRH |
350:
TIQVYRLSKY | NTEEFITVYP | TDPPKDWPVV | TLIAEDDRHY | NIPVRVCEET |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Mouse
Human
Human
ELISA Kit for Human Ubiquitin thioesterase otulin
ELISA Kit for Human Ubiquitin thioesterase otulin
ELISA Kit for Human Ubiquitin thioesterase otulin
ELISA Kit for Human Ubiquitin thioesterase otulin
CLIA Kit for Human Ubiquitin thioesterase otulin
CLIA Kit for Human Ubiquitin thioesterase otulin
CLIA Kit for Human Ubiquitin thioesterase otulin
CLIA Kit for Human Ubiquitin thioesterase otulin
Polyclonal Antibody for Human Ubiquitin thioesterase otulin
Polyclonal Antibody for Human Ubiquitin thioesterase otulin
Polyclonal Antibody for Human Ubiquitin thioesterase otulin
Polyclonal Antibody for Human Ubiquitin thioesterase otulin
Monoclonal Antibody for Human Ubiquitin thioesterase otulin
Monoclonal Antibody for Human Ubiquitin thioesterase otulin
Monoclonal Antibody for Human Ubiquitin thioesterase otulin
Monoclonal Antibody for Human Ubiquitin thioesterase otulin
Protein for Human Ubiquitin thioesterase otulin
Protein for Human Ubiquitin thioesterase otulin
Protein for Human Ubiquitin thioesterase otulin
Protein for Human Ubiquitin thioesterase otulin
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 79-352 OF MUTANT CYS-129;X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 79-352 OF MUTANT CYS-129 IN COMPLEX WITH LINEAR DIUBIQUITIN;FUNCTION;INTERACTION WITH RNF31 AND DVL2;MUTAGENESIS OF CYS-129